Powerbone Dental Putty is a fully resorbing, mouldable, self-hardening, synthetic bone graft which delivers up to 50% new bone in 12 to 16 weeks*.

Powerbone Dental Putty is a trusted material with an innovative combination of Silicate Substituted β-tricalcium phosphate in a high-viscosity cellulose viscoelastic.  This innovative combination is key to its success.

The lowest value item will be supplied as the goodwill unit. 

Why choose Powerbone Dental Putty? 

EASE OF USE

• Pre-mixed syringe saves time -unlike cements containing calcium sulphate, which need mixing.

• No fixed working time – unlike cements containing calcium sulphate, which have restricted working times.

• Resilience to wash away – even in a wet field – unlike cements containing calcium sulphate

• Ergonomically curved syringe with finger grips  – unlike some cements, which use cheap diabetic syringes.

NO MEMBRANE 

• The built-in viscoelastic stabilises the graft without needing a membrane. The high viscosity formulation delivers stability, self-containment and resilience to micromovement – ideal for minimal access approaches with site-specific flaps.

PREMIUM PERFORMANCE

• Up to 50% new bone in 12 to 16 weeks, proven by human dental histology*. 

• Significantly enhanced bone regeneration compared to β-tricalcium phosphate. (3,4)

• Regenerates bone radiographically and histologically equivalent to autogenous bone. (7)

HOW DO POWERBONE GRAFTS WORK?

Watch a short animation highlighting the osteoinductive and osteoconductive features of Powerbone Bone Grafts.

ENHANCED SAFETY

• As a 100% synthetic product, Powerbone eliminates risks associated with xenograft and allograft.

COMPLETE RESORPTION 

In line with bone healing and remodelling, making Powerbone Dental Putty ideal for:

• Socket grafting.

  • Perfect socket fill.

  • Seal with a cross suture over Ora-Aid self-adhering wound barrier or PeriAcryl Oral Adhesive. 

  • Protocol video at https://youtu.be/4iMnZ-KgKN0

• 3-walled GBR defects.

  • One-stage simultaneous graft and implant placement.

  • Two-stage- traditional GBR. 

• Sinus Lift.

• Bony Cysts.

  • Alone or as retention of Powerbone, fully synthetic bone graft granules

UNIQUE FORMULATION 

• Contains a highly porous form of Silicate Substituted βeta-Tricalcium Phosphate (Peer-reviewed over 12 years) developed by St Mary’s University, London.

• High-viscosity cellulose viscoelastic carrier supplemented with trace ZrO2 (0.1%) for antibacterial efficacy and radiopacity.

RADIOPAQUE FOR CLEAR FOLLOW-UP

Resorption of all Powerbone grafts can be followed easily on x-ray – an important feature compared to standard β-TCP, which can be difficult to detect at review.

EVIDENCE BASE

• Highly porous matrix (c70%) enabling rapid revascularisation and excellent space for new bone across the entire three-dimensional structure.

• Induces angiogenesis and fast apatite formation (1,2,5).

• Greater bone fusion and significantly enhanced bone regeneration compared to pure β-TCP. (3,4)

• Comparisons to rhBMP-2 in terms of bone growth and fusion (7)

• Biomechanically, radiographically, and histologically equivalent to autograft (7)

MEMBRANE-FREE PROTOCOL

Membrane Free Protocol_Form Stable Dental Grafts_25

SPEC SHEET

Powerbone Dental Putty_Regen Store

FEATURED CASE

Implant and Grafting Nasopalatine duct_Dr M Leventis_Low Res

CREATED BY EXPERTS FOR EXPERTS

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272.
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4.
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
9.Wheeler, et al. Efficacy of silicated calcium phosphate graft in posterolateral lumbar fusion in sheep. The Spine Journal 7 (2007) 308–317.

*Human Histology & Clinical Images courtesy Dr Minas Leventis. 
Histology_Dr leventis_Powerbone_Dental_Putty_4_TF300623[1]

Powerbone Dental Putty is a fully resorbing, mouldable, self-hardening, synthetic bone graft which delivers up to 50% new bone in 12 to 16 weeks*.

Powerbone Dental Putty is a trusted material with an innovative combination of Silicate Substituted β-tricalcium phosphate in a high-viscosity cellulose viscoelastic.  This innovative combination is key to its success.

The lowest value item will be supplied as the goodwill unit. 

Why choose Powerbone Dental Putty? 

EASE OF USE

• Pre-mixed syringe saves time -unlike cements containing calcium sulphate, which need mixing.

• No fixed working time – unlike cements containing calcium sulphate, which have restricted working times.

• Resilience to wash away – even in a wet field – unlike cements containing calcium sulphate

• Ergonomically curved syringe with finger grips  – unlike some cements, which use cheap diabetic syringes.

NO MEMBRANE 

• The built-in viscoelastic stabilises the graft without needing a membrane. The high viscosity formulation delivers stability, self-containment and resilience to micromovement – ideal for minimal access approaches with site-specific flaps.

PREMIUM PERFORMANCE

• Up to 50% new bone in 12 to 16 weeks, proven by human dental histology*. 

• Significantly enhanced bone regeneration compared to β-tricalcium phosphate. (3,4)

• Regenerates bone radiographically and histologically equivalent to autogenous bone. (7)

HOW DO POWERBONE GRAFTS WORK?

Watch a short animation highlighting the osteoinductive and osteoconductive features of Powerbone Bone Grafts.

ENHANCED SAFETY

• As a 100% synthetic product, Powerbone eliminates risks associated with xenograft and allograft.

COMPLETE RESORPTION 

In line with bone healing and remodelling, making Powerbone Dental Putty ideal for:

• Socket grafting.

  • Perfect socket fill.

  • Seal with a cross suture over Ora-Aid self-adhering wound barrier or PeriAcryl Oral Adhesive. 

  • Protocol video at https://youtu.be/4iMnZ-KgKN0

• 3-walled GBR defects.

  • One-stage simultaneous graft and implant placement.

  • Two-stage- traditional GBR. 

• Sinus Lift.

• Bony Cysts.

  • Alone or as retention of Powerbone, fully synthetic bone graft granules

UNIQUE FORMULATION 

• Contains a highly porous form of Silicate Substituted βeta-Tricalcium Phosphate (Peer-reviewed over 12 years) developed by St Mary’s University, London.

• High-viscosity cellulose viscoelastic carrier supplemented with trace ZrO2 (0.1%) for antibacterial efficacy and radiopacity.

RADIOPAQUE FOR CLEAR FOLLOW-UP

Resorption of all Powerbone grafts can be followed easily on x-ray – an important feature compared to standard β-TCP, which can be difficult to detect at review.

EVIDENCE BASE

• Highly porous matrix (c70%) enabling rapid revascularisation and excellent space for new bone across the entire three-dimensional structure.

• Induces angiogenesis and fast apatite formation (1,2,5).

• Greater bone fusion and significantly enhanced bone regeneration compared to pure β-TCP. (3,4)

• Comparisons to rhBMP-2 in terms of bone growth and fusion (7)

• Biomechanically, radiographically, and histologically equivalent to autograft (7)

MEMBRANE-FREE PROTOCOL

Membrane Free Protocol_Form Stable Dental Grafts_25

SPEC SHEET

Powerbone Dental Putty_Regen Store

FEATURED CASE

Implant and Grafting Nasopalatine duct_Dr M Leventis_Low Res

CREATED BY EXPERTS FOR EXPERTS

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272.
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4.
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
9.Wheeler, et al. Efficacy of silicated calcium phosphate graft in posterolateral lumbar fusion in sheep. The Spine Journal 7 (2007) 308–317.

*Human Histology & Clinical Images courtesy Dr Minas Leventis. 
Histology_Dr leventis_Powerbone_Dental_Putty_4_TF300623[1]

• Maximum Diameter 10mm. (Ring is slightly compressible)

• Hole of 3.3mm. (Ring will compress to accommodate a wider implant diameter.)

• Trim to fit. (The maximum height of the product as packaged is 6.5mm.) 

UNIQUE FORMULATION

Resorbable polymer lattice embedded with bone graft composed of silicate-substituted beta-TCP micro granules (0.05-0.1mm)

• • Silicate resorption induces angiogenesis, fast apatite formation (1,2,5) and accelerated bone healing.

  • Beta TCP provides an osteoconductive scaffold to support new bone formation. 

FLEXIBLE APPLICATION

• Can be wetted before application – saline, blood, or centrifuged blood products.

• Can be trimmed before application.

FULL RESORPTION

• • • Silicate component resorbs first, followed by the Beta-TCP.

    • Polymer matrix resorption in 6 months. 

Micro graft particles are embedded in a flexible synthetic sponge and presented as a socket-shaped cone for easy placement and self-supporting retention.

Requires no special surgical skills or instruments.   Powerbone Sponge Graft contains zero animal or cadaveric tissue, eliminating the need for material consent.  

TECHNICAL

• 50% *silicate substituted βeta-TCP (0.05-0.1mm) porous granules

• 50% flexible synthetic macroporous matrix of polylactide with caprolactone. 

• Fully resorbing.

• 16mm x 10mm bullet-shaped self-supporting cone (swells on application).

FEATURES

• Pre-shaped to match socket morphology.

• Easily trim to fill multi-root or other defects. 

• Swells on application to enhance retention.

• Contains no animal or cadaver tissue and is fully resorbable.

• Fully resorbed in 4 to 6 months with no residue remaining.

1. Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2. Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3. Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 20
17, 8, 1–13.
4. Registered trade mark of Geistlich Pharma AG, Bahnhofstrasse 40 Wolhusen, Switzerland.

SAFETY

The first synthetic alternative to autogenous, allograft or xenograft bone plate/lamella graft. Completely free from animal or human tissue. 

FORMULATION

• Micro silicate substituted βeta-Tricalcium Phosphate synthetic graft (0.05-0.1mm) embedded in a resorbable Polylactide matrix similar to that used for adsorbing sutures. 

• 25mm x 10mm x 1mm.

RESORPTION

• Silicate resorption occurs first inducing angiogenesis and appetite formation (1,2,5) in a process biomechanical and histologically equivalent to autograft (1).

• Beta-TCP provides an osteoconductive scaffold for new bone, resorbing in line with bone healing.

• Resorption of the polylactide matrix begins at 3 months and is complete at 12 to 18 months.

INDICATIONS – THE SHELL TECHNIQUE

Powerbone Cortical plate is used to create a biological container which is filled with bone graft.* Numerous studies highlight the hard tissue gains possible with this type of technique. (8) 

TECHNIQUE

• The host bone is perforated to create a bleeding site. We recommend Decortication drill. 

• Pre-drill Powerbone Cortical plate. 

• Fix Powerbone Cortical plate using Powerbone Fixation Screws or equivalent. Use at least 2 screws to ensure stability. 

• Smooth edges of the Powerbone Cortical Plate with a burr.

• Fill the space between the plate and the defect with graft material*.  

• Cover with a barrier membrane and ensure tension-free soft tissue closure.

*BONE GRAFT FILL OPTIONS

• Autogenous bone can be collected with Bone Scraper or Bionnovation Bone Collection Drill  and used alone or with the addition of:

  • Powerbone Silicate Substitutedβeta-Tricalcium Phosphate granules. (Fully resorbing graft)

  • Powerbone Biphasic granules (Slow resorbing graft).

  • Powerbone Silicate Substitutedβeta-TCP Dental Putty (Fully resorbing graft. Form Stable Graft Putty).

1. Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253. 
2. Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596. 
3. Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490 
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 20 17, 8, 1–13. 
7. Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
8. Khoury F. (2017) Augmentation of severe bony defects with intraoral bone grafts: biological approach and long-term results. http://dx.doi.org/10.1016/j.ijom.2017.02.099

SYRINGE: Application via osteotomy, micro window or short cannulae. (Luer Lock 2.5mm lumen)

CARRIER: Medium viscosity cellulose viscoelastic.  (Blue Package)

GRAFT:  Small granule silicate Substituted βeta-TCP developed by St Marys University, London. (Peer-reviewed over 12 years)

WHY POWERBONE PUTTY?

No mixing – apply directly from the syringe in closed sites such as:

• Deep Peri-Implant ‘jumping space’.

• Sinus lift with Micro Window or Osteotomy delivery.  Youtube video at https://youtu.be/xFiWcTEC_DcvI

• Deep Bony cysts.

WHY SILICATE SUBSTITUTED BETA TCP? 

• Silicate substituted beta TCP possesses a ‘premium performance’ with results ‘radiographically and histologically equivalence to autograft’. (7)

CREATED BY EXPERTS FOR EXPERTS

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272.
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4.
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
9.Wheeler, et al. Efficacy of silicated calcium phosphate graft in posterolateral lumbar fusion in sheep. The Spine Journal 7 (2007) 308–317

• 1 x Degranulation Kit

• 1 x Powerbone Dental Putty (0.3cc)

• 1 x Powerbone Dental Putty (0.5cc)

• 1 x Biphasic Sponge Graft

• 3 x Ora-Aid self-adhering external wound barriers. 

• 3 x Periacryl Tissue Adhesive single-use vials. 

• 3 x PGCL Monofilament Adsorbing Micro surgical sutures.

Powerbone is shown to regenerate up to 50% new bone in human histology at 12 to 16 weeks.  

DEGRANULATION KIT.  Quickly and easily remove granulation tissue to allow unimpeded bone healing. 

POWERBONE DENTAL PUTTY. Powerbone Dental Putty is a fully resorbing, mouldable, self-hardening, synthetic bone graft.  Supplied pre-mixed in an ergonomic syringe. 

POWERBONE GRANULES.  Powerbone Granules are highly porous, absorbent and fully resorbing. Ideal for larger sites or mixing with blood products and medicines. 

BIPHASIC SPONGE GRAFT. Dense haemostatic sponge with biphasic bone graft for socket preservation when an implant is not scheduled.

ORA-AID.  Self-adhering barrier film accelerates healing in graft and implant wounds, including open sockets, soft tissue donor and recipient sites. 

PERIACRYL TISSUE ADHESIVE.  Sets in seconds, lasts weeks. Ideal for small open healing sites, wound sealing, soft tissue donor and recipient sites and suture reinforcement. 

PGCL MONOFILAMENT ADSORBING SUTURES. Easy pull through, knotting and minimal inflammation. 70% strength at 7 days and 40% at 14 days. 

REFERENCES covering silicate substituted beta tri calcium phophate bone grafts.
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272.
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4.
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
9.Wheeler, et al. Efficacy of silicated calcium phosphate graft in posterolateral lumbar fusion in sheep. The Spine Journal 7 (2007) 308–317.

Image for reference only and does not show the exact kit you will receive. 

Powerbone Dental Putty is a trusted material with an innovative combination of Silicate Substituted β-tricalcium phosphate in a high-viscosity cellulose viscoelastic.  This innovative combination is key to its success.

Why choose Powerbone Dental Putty? 

EASE OF USE

• Pre-mixed syringe saves time -unlike cements containing calcium sulphate, which need mixing.

• No fixed working time – unlike cements containing calcium sulphate, which have restricted working times.

• Resilience to wash away – even in a wet field – unlike cements containing calcium sulphate

• Ergonomically curved syringe with finger grips  – unlike some cements, which use cheap diabetic syringes.

NO MEMBRANE 

• The built-in viscoelastic stabilises the graft without needing a membrane. The high viscosity formulation delivers stability, self-containment and resilience to micromovement – ideal for minimal access approaches with site-specific flaps.

PREMIUM PERFORMANCE

• Up to 50% new bone in 12 to 16 weeks, proven by human dental histology*. 

• Significantly enhanced bone regeneration compared to β-tricalcium phosphate. (3,4)

• Regenerates bone radiographically and histologically equivalent to autogenous bone. (7)

HOW DO POWERBONE GRAFTS WORK?

Watch a short animation highlighting the osteoinductive and osteoconductive features of Powerbone Bone Grafts.

ENHANCED SAFETY

• As a 100% synthetic product, Powerbone eliminates risks associated with xenograft and allograft.

COMPLETE RESORPTION 

In line with bone healing and remodelling, making Powerbone Dental Putty ideal for:

• Socket grafting.

  • Perfect socket fill.

  • Seal with a cross suture over Ora-Aid self-adhering wound barrier or PeriAcryl Oral Adhesive. 

  • Protocol video at https://youtu.be/4iMnZ-KgKN0

• 3-walled GBR defects.

  • One-stage simultaneous graft and implant placement.

  • Two-stage- traditional GBR. 

• Sinus Lift.

• Bony Cysts.

  • Alone or as retention of Powerbone, fully synthetic bone graft granules

UNIQUE FORMULATION 

• Contains a highly porous form of Silicate Substituted βeta-Tricalcium Phosphate (Peer-reviewed over 12 years) developed by St Mary’s University, London.

• High-viscosity cellulose viscoelastic carrier supplemented with trace ZrO2 (0.1%) for antibacterial efficacy and radiopacity.

RADIOPAQUE FOR CLEAR FOLLOW-UP

Resorption of all Powerbone grafts can be followed easily on x-ray – an important feature compared to standard β-TCP, which can be difficult to detect at review.

EVIDENCE BASE

• Highly porous matrix (c70%) enabling rapid revascularisation and excellent space for new bone across the entire three-dimensional structure.

• Induces angiogenesis and fast apatite formation (1,2,5).

• Greater bone fusion and significantly enhanced bone regeneration compared to pure β-TCP. (3,4)

• Comparisons to rhBMP-2 in terms of bone growth and fusion (7)

• Biomechanically, radiographically, and histologically equivalent to autograft (7)

MEMBRANE-FREE PROTOCOL

Membrane Free Protocol_Form Stable Dental Grafts_25

SPEC SHEET

Powerbone Dental Putty_Regen Store

FEATURED CASE

Implant and Grafting Nasopalatine duct_Dr M Leventis_Low Res

CREATED BY EXPERTS FOR EXPERTS

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272.
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4.
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.
9.Wheeler, et al. Efficacy of silicated calcium phosphate graft in posterolateral lumbar fusion in sheep. The Spine Journal 7 (2007) 308–317.

*Human Histology & Clinical Images courtesy Dr Minas Leventis. 
Histology_Dr leventis_Powerbone_Dental_Putty_4_TF300623[1]

A porous bone with inductive and conductive properties that resorbs fully in line with bone healing whilst containing no animal or human tissue.

PREMIUM PERFORMANCE

• Highly porous (c70%), enabling rapid revascularisation and excellent space for new bone across the entire structure.

• Attracts cells, induces angiogenesis and apatite formation (1,2,5).

• Significantly enhanced bone regeneration compared to pure β-TCP. (3,4)

• Biomechanically, radiographically, and histologically equivalent to autograft (7)

• Peer-reviewed over 12 years.

UNIQUE FORMULATION

• Pure Silicate-substituted βeta-Tricalcium Phosphate (β-TCP).

FLEXIBILITY

• Use alone or to bulk out autogenous bone particles.

• Infill with space-creating devices such as Titanium Mesh, Cortical Plate or Powerbone Adsorbing Polymer Barrier.

• Ideal carrier for antibiotics or as a basis for sticky bone when mixed with centrifuged blood products.

EASY FOLLOW-UP

Resorption of Powerbone grafts can be followed on x-ray – an important feature compared to standard β-TCP.

DOWNLOADS AND VIDEOS

Powerbone Crunch Graft_Oct20

Sticky Bone Protocol_Powerbone at Regen Store_Sept20

Sticky Bone Video Tutorial (webinar) with Dr Mohamed El-Mohab.

COMPANION PRODUCTS

Powerbone Resorbable Synthetic Membrane.

*REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253. 
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596. 
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490. 
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272. 
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4. 
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478. 

WHY POWERBONE FLEX?
A contained bone defect can be managed with POWERBONE DENTAL PUTTY due to its easy syringe delivery, defect moulding and stability without requiring a large flap and membrane for stability.  However, form stable grafts and bone cements are less suitable for flat surfaces where the defect is not contained or does not present a concavity, which is where POWERBONE FLEX is indicated. 

WHAT IS POWERBONE FLEX?
A space-creating, flexible tissue support matrix within which micro Powerbone granules are embedded on the bony side and a compressed barrier layer is presented on the soft tissue side (see image below). Powerbone Flexible Graft is fully resorbing and contains no animal or cadaver cells.

USING POWERBONE FLEX
Powerbone Flex can be trimmed with scissors, used alone, or pre-soaked with saline, blood, centrifuged cells or medicines. Powerbone Flex can be applied as a secondary tissue support matrix after a defect is regenerated with Powerbone Dental Putty.

Animation of Powerbone Flex in a ridge augmentation with simultaneous implant placement and bone surface decortication.   

HOW IS POWERBONE FLEXIBLE GRAFT PRESENTED?

1. Outer barrier layer.

2. Inner matrix containing embedded micro bone graft.

WHAT SIZES OF POWERBONE FLEXIBLE GRAFT ARE AVAILABLE?

• 15 x 20mm (x 2mm).

• 25 x 25mm (x 2mm or 4mm).

• 25 x 50mm (x 4mm).

RESORPTION OF POWERBONE FLEX

• Silicate part of the embedded Powerbone graft resorbs first, inducing angiogenesis and fast apatite formation (1,2,5)

• Beta TCP part of the embedded Powerbone graft, resorbs over 3 to 4 months, providing a scaffold to support new bone formation. 

• Polymer matrix fibres resorb in 5 to 8 months. 

CASE HISTORY – Powerbone Flexible Graft as peri-implant onlay. 

Powerbone Flexible Graft_Peri implant onlay_Feb 24

LINKED PRODUCTS      Fixation     Sutures 

Powerbone Flexible Graft – CREATED BY EXPERTS FOR EXPERTS

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253.
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596.
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13.
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4. 
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478.