Ti-oss bone is presented with an OCP hydrophilic surface coating.  Octa calcium phosphate (OCP) encourages fast bone formation.

-> Enhanced clot adhesion and improved osteoblast retention compared to alternatives.  

(OCP bio-activity paper_Ti-Oss) 

3. UNIQUE PROCESSING.

All naturally derived grafts (xenograft and allograft) must be processed before use in another human.  Processing with high heat creates a denser material (more crystalline) that the body is less able to remodel.  By contrast, Tio-oss is processed with mid-level temperature, supplemented by chemical and gas washing. This results in a higher percentage of material the body can replace rather than one it treats more as a foreign body with fibrous encapsulation. 

-> 15% graft remnants v 35% for Bio-Oss (Yoona Jung / Valentin, JOMI 2018. 33 (6) @1345=1350) 

->Superior bone fill and bone density compared to Allograft (DFDBA –Najeeb and co-workers)

1. (Lee and Co-workers). Calvarial defects at 8 weeks. Sangho, Korean University Hospital, OMF Dept, Jan 24.  Ti-oss has complete new bone infill compared to partial bone infill in the Bio-oss group of 6 samples.

OTHER CASE STUDIES

Ridge Augmentation Using Ti-oss in the Aesthetic Zone_08_25

Ti-oss December 2023

Ti-oss Case Documentation_Apr24

Pricing comparison: Geistlich Bio-Oss Granules 0.25-1mm 0.5g at £88.73 (ex. VAT). BF Mulholland (NI) web site (June 2023). 
Brand comparisons: Ti-oss & Bio-Oss in new bone formation, Jun, Sangho, Korea University Oral Maxillo Facial Dept. Ti-oss and OCSB (Nibec co), Yonsei University, Seoul, Korea. 

STUDIES: https://www.ti-oss.com/research-and-articles Human Sinus Bone Formation Study Human Cyst.   Cavity Bone Formation Study, ​Rabbit Tibia.  12 Weeks Study Mouse Calvarial Defect Study

REFERENCES:

Jee-Ho Lee. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study. Rabbit Tibia 12 Weeks Comparison Study between Ti-oss® (Chiyewon Co.) & OCSB® (Nibec Co.). Clinical Report: Sinus Lift (Socket Lift), Vertical & Horizontal Augmentation. Histomorphometric Study on Healing of Critical Sized Defect in Rat Calvaria Using Two Different Bovine Grafts. Comparison of Ti-oss® & Bio-oss® in New Bone Formation on Rat Calvarial Defect in 8 Weeks. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study. Ti-oss® Resorption by Osteoclast Found in 8-Week Rat Model. Solution for Sinus Membrane Tear Using PRP & Ti-oss® Bone Graft in One-stage Approach. Socket grafting using a large particulate Xenograft as a prelude to implant placement: A case report and histology. Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration. Yoona Jung Three-Dimensional Radiographic Bone Fill Evaluation Using Octacalcium Phosphate-Coated Deproteinized Bovine Bone Material (Ti-Oss Bone Graft) and Demineralized Freeze-Dried Bone Allograft (DFDBA) in Three-Walled Defects. Immediate Loading Post-extraction Implant in the Aesthetic Region Following Trauma. Horizontal and Vertical Ridge Augmentation in the Esthetic Zone. Immediate Loading with Many Complicated Factors (severe periodontal disease, collapsed occlusion, Immediate extraction)

Guided bone regeneration procedure for implant placement in the esthetic zone A Case Report. A Rare Case Report of Idiopathic Infected Radicular Cyst.

*Bi-oss is a registered trademark of Geistlich Biomaterials, Wolhusen, Switzerland and is used here for comparison purposes only.