Ti-oss xenograft delivers Predictable Long-Term Results.

Ti-oss delivers more bone than Bio-oss¹ with superior bone fill and density compared to Allograft² at a lower cost*

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TI-OSS – THREE DIFFERENCES KEY TO CLINICAL SUCCESS 

PORE SIZE AND DENSITY

Ti-oss uses only the cancellous portion, which is more porous and less dense than grafts containing cortical parts, such as Bio-oss, Straumann Xenograft and mixes of processed allograft.

->High porosity is a prerequisite to clot adsorption and blood penetration.   

->High Porosity means less graft is needed. 1.0g of Ti-oss is equivalent to 2.3cc. By comparison, 1g of Bio-Oss standard particle is equivalent to 2cc.

PROCESSING

Ti-Oss is processed using mid-level temperature and controlled vitrification. This creates an optimal surface (see below) and a higher proportion of material the body can replace rather than high temperature procesing wihc creates a denser, more crystalline form that the body cannot remodel. 

• All xenograft (animal) and allograft (another human) tissue must be processed to make them safe for use.

• Traditional processing, as used for Bio-Oss or Cerabone, uses high heat, creating a denser, more crystalline material that the body is less able to remodel.

• When faced with dense materials, the body treats them as a foreign body and often encapsulates remnants in fibrous tissue. 

-> 22.7 graft remnants v 26.3% for Bio-Oss (Yoona Jung) with up to 35% reported by Valentin (JOMI 2018. 33 (6) @1345-1350)

SURFACE PROPERTIES

Ti-oss is created with a roughened Octa Calcium Phosphate hydrophilic surface coating, shown to:  

->Encourage ‘fast bone formation’ and ‘exert a positive effect on the osteoinductive properties of biomaterials’ 

-> Enhance clot adhesion and improve osteoblast retention compared to alternatives.  

OCP bio-activity paper_Ti-Oss | OCP inductive study

Yoona Jung 1,2,†, Won-Hyeon Kim 1,3,†, Sung-Ho Lee 1,4,†, Kyung Won Ju 1,4, Eun-Hee Jang 5, Sung-O Kim 5, Bongju Kim 1,* and Jong-Ho Lee 4,*Materials 2020, 13, 4391; doi:10.3390/ma13194391

LATEST NEWSLETTERS

OCP coating has a positive effect on the osteoinductivity of biomaterials_2026.07_38

2026.05_News 36_Case_Dr. L C. Arenaza Leal_Achieving Reliable and Predictable GBR Outcomes in the Esthetic zone. LOW RES

Ti-oss_Horizontal & Vertical Augmentation_47 months follow-up. 2026.04_Ed 35

Newsletter 34_Ti-oss in Bilateral Sinus at 36 months_Mar26

1_updated_2025.11_Edition 30_Dr. Lina C. Arenaza Leal_Predictable GBR in the Esthetic Zone (1)

STUDY LIBRARY: https://www.ti-oss.com/research-and-articles

OTHER STUDY TITLES:

• (1) Yoona Jung 1,2,†, Won-Hyeon Kim 1,3,†, Sung-Ho Lee 1,4,†, Kyung Won Ju 1,4, Eun-Hee Jang 5, Sung-O Kim 5, Bongju Kim 1,* and Jong-Ho Lee 4,*Materials 2020, 13, 4391; doi:10.3390/ma13194391
• (2) Najeeb et al, Dentistry, 2019 | Volume 2 | Article 1038. (DFDBA Allograft and Ti-oss)
• Human Sinus Bone Formation Study, Human Cyst.   Cavity Bone Formation Study, ​Rabbit Tibia.  12-Week Study Mouse Calvarial Defect Study.
• Jee-Ho Lee. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study.
• Rabbit Tibia 12 Weeks Comparison Study between Ti-oss® (Chiyewon Co.) & OCSB® (Nibec Co.).
• Clinical Report: Sinus Lift (Socket Lift), Vertical & Horizontal Augmentation. Histomorphometric Study on Healing of Critical Sized Defect in Rat Calvaria Using Two Different Bovine Grafts.
• Comparison of Ti-oss® & Bio-oss® in New Bone Formation on Rat Calvarial Defect in 8 Weeks.
• Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study.
• Ti-oss® Resorption by Osteoclasts Found in an 8-Week Rat Model.
• Solution for Sinus Membrane Tear Using PRP & Ti-oss® Bone Graft in One-stage Approach.
• Socket grafting using a large particulate Xenograft as a prelude to implant placement: A case report and histology.
• Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration. Yoona Jung.
• Three-Dimensional Radiographic Bone Fill Evaluation Using Octacalcium Phosphate-Coated Deproteinized Bovine Bone Material (Ti-Oss Bone Graft) and Demineralised Freeze-Dried Bone Allograft (DFDBA) in Three-Walled Defects.
  Immediate Loading Post-extraction Implant in the Aesthetic Region Following Trauma.
• Horizontal and Vertical Ridge Augmentation in the Esthetic Zone.
• Immediate Loading with Many Complicated Factors (severe periodontal disease, collapsed occlusion, Immediate extraction).
• Guided bone regeneration procedure for implant placement in the esthetic zone: A Case Report. A Rare Case Report of Idiopathic Infected Radicular Cyst.
• Brand comparisons: Ti-oss & Bio-Oss in new bone formation, Jun, Sangho, Korea University Oral Maxillofacial Dept. Ti-oss and OCSB (Nibec co), Yonsei University, Seoul, Korea.

* Bi-Oss is a registered trademark of Geistlich Biomaterials, Wolhusen, Switzerland and is used here for reference and comparison purposes only.

• Lee and co-workers. Calvarial defects – Ti-oss, complete bone infill, Bio-Oss partial bone infill.
• Pricing comparison: Geistlich Bio-Oss Granules 0.25- 1 mm 0.5 g at £88.73 (ex. VAT). BF Mulholland (NI) website (June 2023).