Ti-oss OCP coated bovine xenograft – more bone than Bio-oss at 25% less cost. 

Ti-oss represents the first significant differences in xenograft material science in over 4 decades.

Researchers at Ti-oss developed a unique process and particle coating technology which ensures optimal characteristics for handling, angiogenesis and cell differentiation, proven in studies to deliver: 

• Enhanced human bone formation – 23% new bone at 26-32 weeks. (Lee and Co-workers)

• A quicker graft turnover than Bio-oss from Geistlich Biomaterials with 15% graft remnants v 36% for Bio-Oss (Yoona Jung / Valentini, JOMI, 2018 Nov/Dec;33(6):1345-1350) 

• Superior bone fill and bone density compared to Dental Allograft DFDBA. (Najeeb and co-workers)

Change the Dynamic-switch your xenograft to Ti-oss and enjoy more bone than Bio-Oss at 25% less cost.

Comparison of new bone formation with Ti-oss and Bio-oss in rat calvarial defect at 8 weeks. Jun Sangho, Pilot Study, Korean University Hospital, Oral and Maxillofacial Dept. Jan 24

KEY Ti-OSS FEATURES

Unique processing.

Ti-oss uses 100% cancellous bone. Most xenografts use a mix of cortical and cancellous bone. All xenografts must be processed before use in humans with high heat processing creating harder, more dense structures with fewer micropores, not favoured by new bone cells.  Ti-oss applies a sophisticated processing using low temperatures supplemented by pH control chemicals,s which retains optimal porosity and pore structure, ensuring excellent wettability, surface area and angiogenesis – the precursor to quick vascularisation and early healing. 

Osteopromoting surface.

Ti-oss bone is presented with an OCP surface coating.  OCP (octa calcium phosphate) is shown to encourage fast bone formation,n with histological measures demonstrating enhanced osteoblast adhesion compared to alternatives.  Read more in the OCP bio-activity paper_Ti-Oss 

High Porosity.

Osteoblasts, oxygen and nutrients necessary for new bone formation are delivered inside a graft via new blood vessel ingrowth (angiogenesis). Maximum angiogenesis occurs when the pore size is around 300 microns.  Ti-oss bone uses only cancellous bone – naturally the most porous which combined with its unique processing ensures an average pore size of 300 – 400 microns. This compares more favourably than Bio-oss which shows an average pore size of 100-200 microns. 

A=Bio-oss shown on the left, and B=Ti-oss shown on the right

4. Greater volume fill

Higher porosity means less Ti-oss is needed to fill the same size defect defect compared to alternatives from Geistlich Biomaterials (Bio-oss) and Nibec as shown in the test image for volume fill of 0.5g. 

Volume fill (0.5g) left to right – Ti-oss, Bio-Oss, Nibec.

5. Economically efficient.

Ti-oss OCP-coated xenograft is available at a list price some 20% less than Bio-oss from Geistlich Biomaterials.  First orders receive 1 free for 3 units, with all subsequent orders enjoying 1 free for every 5 purchased. 

Switch your xenograft to Ti-oss and enjoy more bone than Bio-Oss at up to 25% less cost!

LATEST CASE STUDIES

Ridge Augmentation Using Ti-oss in the Aesthetic Zone_08_25

Ti-oss December 2023

Ti-oss Case Documentation_Apr24

SYRINGE DELIVERY FORM.

Ti-oss OCB-coated xenograft bone is also available in a filter syringe unit. Contact us if this delivery form appeals to you. 

Pricing comparison: Geistlich Bio-Oss Granules 0.25-1mm 0.5g at £88.73 (ex. VAT). BF Mulholland (NI) web site (June 2023)

Brand comparisons: Ti-oss and Bio-Oss in new bone formation, Jun, Sangho, Korea University Oral Maxillo Facial Dept. Ti-oss and OCSB (Nibec co), Yonsei University, Seoul, Korea. 

STUDIES Web Link to articles: https://www.ti-oss.com/research-and-articles Human Sinus Bone Formation Study Human Cyst.   Cavity Bone Formation Study, ​Rabbit Tibia.  12 Weeks Study Mouse Calvarial Defect Study REFERENCES

Jee-Ho Lee. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study. Rabbit Tibia 12 Weeks Comparison Study between Ti-oss® (Chiyewon Co.) & OCSB® (Nibec Co.). Clinical Report: Sinus Lift (Socket Lift), Vertical & Horizontal Augmentation. Histomorphometric Study on Healing of Critical Sized Defect in Rat Calvaria Using Two Different Bovine Grafts. Comparison of Ti-oss® & Bio-oss® in New Bone Formation on Rat Calvarial Defect in 8 Weeks. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study. Ti-oss® Resorption by Osteoclast Found in 8-Week Rat Model. Solution for Sinus Membrane Tear Using PRP & Ti-oss® Bone Graft in One-stage Approach. Socket grafting using a large particulate Xenograft as a prelude to implant placement: A case report and histology. Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration. Yoona Jung Three-Dimensional Radiographic Bone Fill Evaluation Using Octacalcium Phosphate-Coated Deproteinized Bovine Bone Material (Ti-Oss Bone Graft) and Demineralized Freeze-Dried Bone Allograft (DFDBA) in Three-Walled Defects. Immediate Loading Post-extraction Implant in the Aesthetic Region Following Trauma. Horizontal and Vertical Ridge Augmentation in the Esthetic Zone. Immediate Loading with Many Complicated Factors (severe periodontal disease, collapsed occlusion, Immediate extraction)

Guided bone regeneration procedure for implant placement in the esthetic zone A Case Report. A Rare Case Report of Idiopathic Infected Radicular Cyst.

*Bi-oss is a registered trademark of Geistlich Biomaterials, Wolhusen, Switzerland and is used here for comparison purposes only.