New Generation Xenografts – Inductive and Bio-Active.

Newer techniques for the processing of bone graft materials bring significant clinical benefits to clinicians experienced with using traditional HA-based xenograft materials.

One such materials is Ti-Oss OCP rich xenograft.

What is Ti-oss?

Ti-oss is a 100% cancellous bone graft substitute derived from bovine prepared using a unique low-temperature process which creates an OCP-rich surface. This surface is shown to stimulate osteoblastic activity. Moreover, the advanced processing ensures an average pore size 3 x that of Bio-Oss which enhances the economic benefits due to greater defect fill per gram.

What is OCP?

OCP or octa calcium phosphate has the chemical structure Ca8H2(PO4)65H2O. Numerous studies confirm that OCP enhances bone regeneration due to osteoblast stimulation during the conversion of OCP into HA and thus induces new bone deposition. This initial step is followed by collagen formation, apatite crystal deposition, and bone mineralization. (1)

OCP and Ti-Oss Histology.

Osteoblasts are directly aligned on the OCP and the newly formed osteoid bone matrix. Osteoblasts are cuboidal indicating active synthesis of bone matrix collagen is occurring. Moreover, an osteoclast cell is seen in contact with osteoblasts and attached
directly to the OCP surface suggesting active resorption. B: newly formed bone. * OCP granule. Osteoclasts arrowed. (1)

More about Ti-Oss OCP-rich xenograft

You can access more information about Ti-oss OCP-rich xenograft here.

References:

1. Octacalcium phosphate (OCP)-based bone substitute materials. Osamu Suzuki. Japanese Dental Science Review (2013) 49, 58—71.
2. Rabbit Tibia 12 Weeks Comparison Study between Ti-oss® (Chiyewon Co.) & OCSB® (Nibec Co.)
3. Clinical Report: Sinus Lift (Socket Lift), Vertical & Horizontal Augmentation
4. Histomorphometric Study on Healing of Critical Sized Defect in Rat Calvaria Using Two Different Bovine Grafts 
5. Comparison of Ti-oss® & Bio-oss® in New Bone Formation on Rat Calvarial Defect in 8 Weeks
6. Bone Regeneration of Macropore Octacalcium Phosphate–Coated Deproteinized Bovine Bone Materials in Sinus Augmentation: A Prospective Pilot Study
7. Ti-oss® Resorption by Osteoclast Found on 8 Weeks Rat Model 
8. Solution for Sinus Membrane Tear Using PRP & Ti-oss® Bone Graft in One-stage Approach
9. Socket grafting using a large particulate Xenograft as a prelude to implant placement: A case report and histology
10. Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration
11. Three-Dimensional Radiographic Bone Fill Evaluation Using Octacalcium Phosphate-Coated Deproteinized Bovine Bone Material (Ti-Oss Bone Graft) and Demineralized Freeze-Dried Bone Allograft (DFDBA) in Three Walled Defects.
12. Immediate Loading Post-extraction Implant in the Aesthetic Region Following Trauma
13. Horizontal and Vertical Ridge Augmentation in the Esthetic Zone
14. Immediate Loading with Many Complicated Factors (severe periodontal disease, collapsed occlusion, Immediate extraction)
15. Guided bone regeneration procedure for implant placement in the esthetic zone A Case Report