Newer techniques for processing bone graft materials offer significant clinical benefits to clinicians experienced with traditional HA-based xenograft materials.

One such material is Ti-oss OCP-rich xenograft.

What is Ti-oss?

Ti-oss is a highly porous bone graft scaffold derived from 100% cancellous bone of bovine origin. Unlike traditional xenografts and some mineralised allografts, Ti-oss is prepared using a chemical and 600-degree temperature process, which retains greater porosity than those treated to high heat – c 1200 degrees.  The process includes a surface treatment with an OCP-rich surface shown to stimulate osteoblastic activity. Moreover, the advanced processing ensures an average pore size 3 x that of Bio-Oss, which enhances the economic benefits due to greater defect fill per gram, as shown in the included image.

1.0g of Ti-oss is equivalent to 2.3cc.

Volume efficiency 0.5g. Ti-oss (L), Bi-Oss (M), Nibec (R). 

What is OCP?

Octa calcium phosphate, has the chemical structure Ca8H2(PO4)65H2O. Numerous studies confirm that OCP enhances bone regeneration due to osteoblast stimulation during the conversion of OCP into HA and thus induces new bone deposition. This initial step is followed by collagen formation, apatite crystal deposition, and bone mineralisation. (1)

OCP and Ti-Oss Histology.

Osteoblasts are directly aligned on the OCP and the newly formed osteoid bone matrix. Osteoblasts are cuboidal, indicating that active synthesis of bone matrix collagen is occurring.

An osteoclast cell is seen in contact with osteoblasts and attached directly to the OCP surface, suggesting active resorption. B: newly formed bone. * OCP granule. Osteoclasts arrowed. (1)

More about Ti-oss xenograft and its predictable performance can be accessed here.

References: See manufacurers clinical library at https://www.ti-oss.com/clinicaldata