Powerbone Crunch - Synthetic Bone Graft

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Description

Significantly enhanced bone regeneration compared to β-TCP (3,4).

Powerbone Crunch is a particulate bone graft that resorbs completely in line with the bone healing sequence making it perfect for all defect types.

PREMIUM PERFORMANCE

  • Highly porous matrix (c70%) enabling rapid revascularisation and excellent space for new bone across the entire three-dimensional structure.

  • Induces angiogenesis and fast apatite formation (1,2,5).

  • Greater bone fusion and significantly enhance bone regeneration compared to pure β-TCP. (3,4)

  • Comparisons to rhBMP-2 in terms of bone growth and fusion (7)

  • Biomechanically, radiographically, and histologically equivalence to autograft (7)

UNIQUE FORMULATION

  • Contains a highly porous form of Silicate Substituted βeta-Tricalcium Phosphate (β-TCP).

  • Peer-reviewed over 12 years.

  • Supplemented with ZrO2 (0.1%) for antibacterial efficacy and radiopacity.

FLEXIBILITY

  • Use alone or to bulk out autogenous bone particles.

  • Ideal carrier for antibiotics or as a basis for sticky bone when mixed with centrifuged blood products.

FORMULATION

  • Contains a highly porous form of Silicate Substituted βeta-Tricalcium Phosphate (β-TCP) supplemented with ZrO2 (0.1%) for antibacterial efficacy and radiopacity.

WHY SILICATE SUBSTITUTED β-TCP?

  • Peer-reviewed over 12 years.

  • Excellent conductivity and numerous reports supporting osteoinductivity, induced angiogenesis and fast apatite formation (1,2,5).

  • Greater bone fusion and significantly enhance bone regeneration compared to pure β-TCP. (3,4)

  • Comparisons to rhBMP-2 in terms of bone growth and fusion (7)

  • Biomechanically, radiographically, and histologically equivalence to autograft (7)

EASY FOLLOW-UP

Resorption of Powerbone grafts can be followed on x-ray – an important feature compared to standard β-TCP.

DOWNLOAD SPEC SHEET: Powerbone Crunch Graft_Oct20

COMPANION PRODUCTS

Powerbone Resorbable Synthetic Membrane.

REFERENCES
1.Iimori Y, Kameshima Y, Yasumori A, Okada K. Effect of solid/solution ratio on apatite formation from CaSiO3 ceramics in simulated body fluid. J Mater Sci Mater Med 2004;15:1247–1253. 
2.Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials 2008;29:2588–2596. 
3.Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490. 
4.Nagineni, Vamsi V., et al. "Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures." Spine 37.20 (2012): E1264-E1272. 
5.Dashnyam, K.; El-Fiqi, A.; Buitrago, J.O.; Perez, R.A.; Knowles, J.C.; Kim, H.-W. A mini-review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J. Tissue Eng. 2017, 8, 1–13. 
6.Test Report Bonegraft Biologic, No: 2018-BME-05-1, 2018-BME-05-2, 2018-BME-05-3 and 2018-BME-05-4. 
7.Licina et al, Comparison of (SiCAP) with (Infuse) in Posterolateral Instrumented Lumbar Fusion Global Spine J 2015;5:471–478. 
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